REZNA 100MG TAB 14sResmetirom is a partial agonist of the thyroid hormone receptor beta (THR ). Resmetirom produced 83. 8% of the maximum response compared to triiodothyronine (T3), with an EC50 of 0. 21 M in an in vitro functional assay for THR activation. The same functional assay for thyroid hormone receptor alpha (THR a) agonism showed 48. 6% efficacy for Resmetirom relative to T3, with an EC50 of 3. 74 M. THR is the major form of THR in the liver, and stimulation
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